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Annexins Molecular Structure to Cellular Function ~ Annexins are a family of proteins involved in some important membranerelated biological processes such as coagulation fibrinolysis apoptosis and inflammation Having been studied since 1977 there are many researches on this family of proteins including a research breakthrough period around 1990s

Annexins From Structure to Function Physiological Reviews ~ The presence of annexins in these cells therefore fits with current models of annexin function in cell matrix adhesion and cell membrane plasticity and remodeling The nematode worm C elegans is somewhat more complex in that it expresses four annexins annexins B5 to B8 of which annexin B7 is the best characterized

Annexins from structure to function ~ Author information 1Institute for Medical Biochemistry Center for Molecular Biology of Inflammation University of Münster Münster Germany Annexins are Ca2 and phospholipid binding proteins forming an evolutionary conserved multigene family with members of the family being expressed throughout animal and plant kingdoms

Annexins From Structure to Function ~ Annexins From Structure to Function VOLKER GERKE AND STEPHEN E MOSS Institute for Medical Biochemistry Center for Molecular Biology of Inflammation University of Mu¨nster Mu¨nster Germany and Department of Cell Biology Institute of Ophthalmology University College London London United Kingdom

PDF Annexins from structure to function Semantic Scholar ~ Many of the annexin cores have been crystallized and their molecular structures reveal interesting features that include the architecture of the annexintype Ca2 binding sites and a central hydrophilic pore proposed to function as a Ca2 channel In addition to the conserved core all annexins contain a second principal domain

The annexins Genome Biology Full Text ~ An intriguing recurring connection between annexins and structural proteins such as actin is suggested by genetic anomalies such as the fusion in Drosophila of an annexin gene with a dynein intermediatechain gene 15 and in Ciona intestinalis of a gene similar on the basis of its exonsplicing pattern

PDF Annexins From structure to function ~ Annexins are members of a polygene family that maintain an evolutionarily conserved structure they can bind with bivalent calcium ions phospholipids and are located on the cell membrane 12 13

Annexin II tetramer structure and function SpringerLink ~ The annexins are a family of proteins that bind acidic phospholipids in the presence of Ca 2 The interaction of these proteins with biological membranes has led to the suggestion that these proteins may play a role in membrane trafficking events such as exocytosis endocytosis and cellcell adhesion

Ca 2 bridging mechanism and phospholipid head group ~ Structural evidence is presented for a ‘Ca2bridging’ mechanism proposed for Ca2 binding interfacial membrane proteins such as annexins protein kinase C and certain coagulation proteins

Annexin an overview ScienceDirect Topics ~ Annexin 1 is a potent inhibitor of the soluble form of phospholipase A2 and has been extensively studied because its expression is induced by synthetic antiinflammatory steroids glucocorticoids These are mainstay medicaments in the treatment of inflammatory disorders such as asthma rheumatoid arthritis